carcinoma workup
IMMUNOHISTOCHEMISTRY
Carcinoma Staining Patterns
Squamous
POS
NEG
Adenocarcinoma
CK5/6
Cam5.2
P63
AE1/AE3
CK7
CK20
Urothelial
Neuroendocrine
CK
CK20
Uroplakin
Thrombomodulin
Synaptophysin
Chromogranin
CD56
-
Vulva
-
Vagina
-
Cervix
-
Anus
-
Lung
-
Esophagus
-
Tongue
-
Larynx
-
Pharynx
-
Tonsils
-
Urinary bladder
-
Ureters
-
Renal pelvis
CK7
CK20
CDX2
CK7
CK20
TTF1
-
Lung
-
Colorectal
CK
+/- MOC31
-
Colorectal
-
Small Intestine
-
Stomach
-
Lung
-
Breast
See workup below
Adenocarcinoma workup
CK7, CK20
Biliary
Tract
CK19, CDX2
CK19
CK7
CK20
CDX2
-
Upper GI Tract
-
Pancreas
-
Biliary Tract
-
Mucinous ovary
CK19
CDX2
CK19
CDX2
-
Upper GI Tract
-
Mucinous ovary
Pancreas
CK7
CK20
-
Thyroid
-
Lung
-
Breast
-
Endometrium
-
Serous Ovary
-
Upper GIT
-
Biliary tract
-
Pancreas
-
Synovial sarcoma
All Stains Negative
CK7
CK20
-
Prostate
-
Kidney
-
Adrenal gland
VIM, PSA/NKX3.1, Melan-A
PSA
VIM
VIM
Melan-A
Melan-A
Prostate
Kidney
Adrenal
NKX3.1
TTF1, Thyroglobulin, ER, CK19
TTF1
TTF1
Thyro
ER
CK19
CK19
Thyroid
Lung
-
Breast
-
Serous ovary
-
Endometrium
-
Biliary tract
-
Synovial sarc
-
Upper GIT
-
Pancreas
CDX2
CDX2
CDX2
Upper GIT
Pancreas
CA125
CA125
CA125
PCR (SYT-SSX-1/2)
Synovial sarcoma (monophasic)
Serous
ovary
-
Breast
-
Endometrium