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carcinoma workup

IMMUNOHISTOCHEMISTRY

Carcinoma Staining Patterns

Squamous
POS
NEG
Adenocarcinoma
CK5/6
Cam5.2
P63
AE1/AE3
CK7
CK20
Urothelial
Neuroendocrine
CK
CK20
Uroplakin
Thrombomodulin
Synaptophysin
Chromogranin
CD56

  • Vulva

  • Vagina

  • Cervix

  • Anus

  • Lung

  • Esophagus

  • Tongue

  • Larynx

  • Pharynx

  • Tonsils

  • Urinary bladder

  • Ureters

  • Renal pelvis

CK7
CK20
CDX2
CK7
CK20
TTF1

  • Lung

  • Colorectal

CK
+/- MOC31

  • Colorectal

  • Small Intestine

  • Stomach

  • Lung

  • Breast

See workup below

Adenocarcinoma workup

CK7, CK20

Biliary

Tract

CK19, CDX2
CK19
CK7
CK20
CDX2

  • Upper GI Tract

  • Pancreas

  • Biliary Tract

  • Mucinous ovary

CK19
CDX2
CK19
CDX2

  • Upper GI Tract

  • Mucinous ovary

Pancreas

CK7
CK20

  • Thyroid

  • Lung

  • Breast

  • Endometrium

  • Serous Ovary

  • Upper GIT

  • Biliary tract

  • Pancreas

  • Synovial sarcoma

All Stains Negative
CK7
CK20

  • Prostate

  • Kidney

  • Adrenal gland

VIM, PSA/NKX3.1, Melan-A
PSA
VIM
VIM
Melan-A
Melan-A

Prostate

Kidney

Adrenal

NKX3.1
TTF1, Thyroglobulin, ER, CK19
TTF1
TTF1
Thyro
ER
CK19
CK19

Thyroid

Lung

  • Breast

  • Serous ovary

  • Endometrium

  • Biliary tract

  • Synovial sarc

  • Upper GIT

  • Pancreas

CDX2
CDX2
CDX2

Upper GIT

Pancreas

CA125
CA125
CA125
PCR (SYT-SSX-1/2)

Synovial sarcoma (monophasic)

Serous 

ovary

  • Breast

  • Endometrium

https://basicmedicalkey.com/immunochemistry-and-molecular-biology-in-cytological-diagnosis/

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