Diabetic Mastopathy (Chronic lymphocytic mastitis)


Chronic Lymphocytic Mastitis (Diabetic Mastopathy)

General

  • Often presents as a discrete mass in young patients with Type 1 Diabetes

  • Similar histologic features can be seen in patients with other autoimmune diseases

  • Ex: Hashimoto's disease; or even in individuals without autoimmune diseases or in men

Histology

  • Breast tissue with dense keloid-like stromal fibrosis (paucicellular, often glassy in appearance)

  • Dense lymphocytic infiltrates surrounding lobules, ducts and blood vessels

  • Lymphocytes are predominantly B-cells (NOTE: there is NO inc risk for lymphoma)

  • Epithelioid stromal cells (myofibroblasts) with enlarged nuclei and small nucleoli


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