Chronic Lymphocytic Mastitis (Diabetic Mastopathy)
General
Often presents as a discrete mass in young patients with Type 1 Diabetes
Similar histologic features can be seen in patients with other autoimmune diseases
Ex: Hashimoto's disease; or even in individuals without autoimmune diseases or in men
Histology
Breast tissue with dense keloid-like stromal fibrosis (paucicellular, often glassy in appearance)
Dense lymphocytic infiltrates surrounding lobules, ducts and blood vessels
Lymphocytes are predominantly B-cells (NOTE: there is NO inc risk for lymphoma)
Epithelioid stromal cells (myofibroblasts) with enlarged nuclei and small nucleoli