A Histology Tour of the GI Tract- Small Intestines Overview



The small intestines consist of the duodenum, jejunum and ileum. This post contains many high yield images that help to identify some of the identifying features of the small intestine. Namely, the presence of microvilli and villi on the mucosal surface increase the surface area present for absorption within the GI tract. In addition to absorptive properties, the small intestines contain a muscular layer to aid in peristalsis (food digestion) and an outer serosal layer for added protection.


Several cell types are encountered in the small and large intestines. Goblet cells and Paneth cells are important landmarks of the intestinal tract. The presence or absence of these (or other cells such as inflammatory cells) can signify an underlying problem depending on the location within the GIT. It is important to know which portions of the GIT the presence of a certain cell type is considered "acceptable" versus indicating something "bad".


There are subtle differences between the duodenum, jejunum and ileum that can help differentiate between them. More specific details regarding the histology of each organ will be covered in separate posts. However, all of the organs in the small intestine contain the same general architecture on histology:

  1. Mucosa (inner most layer)

  2. Lamina propria

  3. Muscularis mucosa/interna

  4. Submucosa

  5. Muscularis externa

  6. Serosa (outermost layer)

Continue reading to familiarize yourself with the general schema of the small intestines.

Now that you have familiarized yourself with the overall picture of the small intestines, you can continue learning about the identifying features for each organ by clicking on the respective post in the GI- Small & Large intestines chapter.

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These posts contain high yield information collected from various educational resources including textbooks, journal articles, educational websites and more. They are intended for educational use only and should NOT be taken as medical advice. I strongly believe the spreading of knowledge and depth of learned information should be encouraged in today's society rather than coveted. Membership is required to view these posts  and should be used solely for educational purposes only.