Pattern-Based Approach to the Liver Biopsy

Updated: Sep 5, 2018

The following content was adapted from the 2012 USCAP short course: Pattern-based algorithms in diagnostic liver pathology presented by Dr. Romil Saxena and Dr. Neil D. Theise.

Assessment of liver architecture

Normal architecture:

  • Sheets of hepatocytes interrupted at uniform intervals by portal tract branches and hepatic venous tributaries of various sizes

  • Scarce fibrous tissue (if present, should surround the portal tracts and central veins)