What is an "Autoimmune Disorder"?

Updated: Apr 3, 2019

The Basics

  • Simply speaking, autoimmune disorders are when the host's inflammatory cells attack "normal/self" tissues causing damage to the host tissues.

  • Autoimmune disorders can occur as a result if B and T cells do not mature properly. Under usual circumstances, this occurs during a process called "tolerance" in which any T and B cells that respond to self-antigen would be either "re-trained" or "removed from duty".

  • Autoimmune disorders have genetic components, often related to HLA alleles, and can be triggered by environmental or infectious stimuli.