High Yield Reviews
Ki67 LOW (<5%)
P53 will show patchy weak positivity
Absence of mitotic figures, apoptosis, prominent nucleoli or loss of polarity
Don't confuse intraepithelial lymphocytes for apoptotic bodies!
Dilated, slit-like spaces
Looks like an intraductal papilloma of the breast at low power
View Virtual Slide
Dense stroma surrounding glands
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Acute vs. Chronic Salpingitis
Granulomatous (TB, Sarcoidosis)
Pelvic Inflammatory Disease (Chlamydia or Gonorrhea)
<-- Click to examine this slide demonstrating chronic salpingitis from schistosomiasis infection. How neat!?!
Most often in fallopian tube
Clinical pic= +/- hx of PID, Amenorrhea, Vaginal bleeding, Pain
Diagnosis = elevated/abnormal HCG levels & ultrasound
D&C (of endometrium) would NOT have fetal parts
Requires emergency surgery
<-- Click to examine this slide demonstrating an ectopic tubal gestation. Notice the chorionic villi present and abundant hemorrhage from rupture of the tube.
Primary tumors of FT are very RARE!
Exclude extension or metastases from endometrium or ovary!
Mets > Primary
Serous Tubal Intraepithelial Lesion/Carcinoma (STIL/STIC)
RFs= BRCA gene mutn, SCOUT lesions (PAX2 loss; cellular outgrowths in whole FT)
Most common in fimbriated end of FT- sample extensively during grossing!
Elongated, hyperchromatic nuclei with mitosis & apoptosis
P53+ (either strongly diffusely positive or completely negative)
Wild type (normal) shows patchy, weak positivity