Fallopian Tube Pathology

Microscope
  • Ki67 LOW (<5%)

  • P53 will show patchy weak positivity

  • Absence of mitotic figures, apoptosis, prominent nucleoli or loss of polarity

    • Don't confuse intraepithelial lymphocytes for apoptotic bodies!​

INTRODUCTION

Normal Fallopian Tube Histology

Adenomatoid Tumor of FT.png
  • Dilated, slit-like spaces

  • Looks like an intraductal papilloma of the breast at low power

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Adenomatoid Tumor

Endometriosis.png
  • Typical histology

    • Endometrial glands​

    • Dense stroma surrounding glands

    • Extravasated RBCs

    • +/- hemosiderin

 

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Endometriosis

Salpingitis with Schistosomiasis.png
  • Acute vs. Chronic Salpingitis

  • Granulomatous (TB, Sarcoidosis)

  • Pelvic Inflammatory Disease (Chlamydia or Gonorrhea)

  • Other

<-- Click to examine this slide demonstrating chronic salpingitis from schistosomiasis infection. How neat!?!

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Salpingitis (Infections of Fallopian Tubes)

Ectopic tubal gestation.png
  • Most often in fallopian tube

  • Clinical pic= +/- hx of PID, Amenorrhea, Vaginal bleedingPain

  • Diagnosis =  elevated/abnormal HCG levels & ultrasound

  • D&C (of endometrium) would NOT have fetal parts

  • Requires emergency surgery 

<-- Click to examine this slide demonstrating an ectopic tubal gestation. Notice the chorionic villi present and abundant hemorrhage from rupture of the tube.

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Ectopic Pregnancy

Microscope Slide
  • Primary tumors of FT are very RARE!

  • Exclude extension or metastases from endometrium or ovary!

FT Tumors...

Mets > Primary

Neoplasms in the Fallopian Tube

STIC.png
  • Serous Tubal Intraepithelial Lesion/Carcinoma (STIL/STIC)

  • RFs= BRCA gene mutn, SCOUT lesions (PAX2 loss; cellular outgrowths in whole FT)

  • Most common in fimbriated end of FT- sample extensively during grossing!​

  • Elongated, hyperchromatic nuclei with mitosis & apoptosis

  • Helpful stains=

    • P53+ (either strongly diffusely positive or completely negative)

      • Wild type (normal) shows patchy, weak positivity​

    • Ki67 inc

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Serous Tubal Intraepithelial Lesion (STIL/C)

Adenomatoid tumor of fallopian tube