Fallopian Tube Pathology

Microscope
  • Ki67 LOW (<5%)

  • P53 will show patchy weak positivity

  • Absence of mitotic figures, apoptosis, prominent nucleoli or loss of polarity

    • Don't confuse intraepithelial lymphocytes for apoptotic bodies!​

INTRODUCTION

Normal Fallopian Tube Histology

Adenomatoid Tumor of FT.png
  • Dilated, slit-like spaces

  • Looks like an intraductal papilloma of the breast at low power

View Virtual Slide

Adenomatoid Tumor

Endometriosis.png
  • Typical histology

    • Endometrial glands​

    • Dense stroma surrounding glands

    • Extravasated RBCs

    • +/- hemosiderin

 

- SEE MORE VIRTUAL SLIDES -

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Endometriosis

Salpingitis with Schistosomiasis.png
  • Acute vs. Chronic Salpingitis

  • Granulomatous (TB, Sarcoidosis)

  • Pelvic Inflammatory Disease (Chlamydia or Gonorrhea)

  • Other

<-- Click to examine this slide demonstrating chronic salpingitis from schistosomiasis infection. How neat!?!

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Salpingitis (Infections of Fallopian Tubes)

Ectopic tubal gestation.png
  • Most often in fallopian tube

  • Clinical pic= +/- hx of PID, Amenorrhea, Vaginal bleedingPain

  • Diagnosis =  elevated/abnormal HCG levels & ultrasound

  • D&C (of endometrium) would NOT have fetal parts

  • Requires emergency surgery 

<-- Click to examine this slide demonstrating an ectopic tubal gestation. Notice the chorionic villi present and abundant hemorrhage from rupture of the tube.

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Ectopic Pregnancy

Microscope Slide
  • Primary tumors of FT are very RARE!

  • Exclude extension or metastases from endometrium or ovary!

FT Tumors...

Mets > Primary

Neoplasms in the Fallopian Tube

STIC.png
  • Serous Tubal Intraepithelial Lesion/Carcinoma (STIL/STIC)

  • RFs= BRCA gene mutn, SCOUT lesions (PAX2 loss; cellular outgrowths in whole FT)

  • Most common in fimbriated end of FT- sample extensively during grossing!​

  • Elongated, hyperchromatic nuclei with mitosis & apoptosis

  • Helpful stains=

    • P53+ (either strongly diffusely positive or completely negative)

      • Wild type (normal) shows patchy, weak positivity​

    • Ki67 inc

View Virtual Slide

Serous Tubal Intraepithelial Lesion (STIL/C)

Adenomatoid tumor of fallopian tube
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These posts contain high yield information collected from various educational resources including textbooks, journal articles, educational websites and more. They are intended for educational use only and should NOT be taken as medical advice. I strongly believe the spreading of knowledge and depth of learned information should be encouraged in today's society rather than coveted. Membership is required to view these posts  and should be used solely for educational purposes only.