Benign Ovarian Pathology
Ovarian tumors can be either primary (arising from the ovary) or metastatic.
Primarily discovered late after disease has already spread to the pelvic surfaces
25,000 women annually; Kills 3/5 of those affected
# of lifetime ovulations
Protective factors (decrease the risk of ovarian cancer)
Low dose aspirin
Primary Ovarian Tumors: An Overview
#1- Surface Epithelial Tumors
#2- Germ Cell Tumors
#3- Sex Cord- Stromal Tumors
What is the most common form of hereditary colorectal cancer syndromes?
A. Familial Adenomatous Polyposis (FAP)
B. Lynch Syndrome (HNPCC)
C. Juvenile polyposis
D. Cowden syndrome
E. Gardner syndrome
What is the most common extra-colonic malignancy in Lynch syndrome?
A. Endometrial cancer
B. Gastric cancer
C. Pancreatic cancer
D. Ovarian cancer
E. Biliary cancer
What germline mutation is present in Lynch Syndrome?
ANS: DNA mismatch repair genes (MMR)
Female patients with Peutz-Jeghers syndrome are also at inc risk of which GYN tumor?
B. Clear cell carcinoma of ovary
C. Leydig cell tumor
D. Germ cell tumors of the ovary
E. Cervical adenoma malignum
What is the manner of inheritance for Peutz-Jeghers syndrome?
ANS: Autosomal dominant
What is the hallmark finding of a Peutz-Jeghers intestinal polyp?
A. Absence of lamina propria around glands
C. Arborizing smooth muscle in lamina propria
D. Monomorphic cells
E. Mucus retention cysts
Dr. Anwar. Online lecture. Osler.org. AP Pathology Review. Female Reproductive Tract.